Paracetamol: A Comprehensive Overview

  • Admin
  • Drug Development
  • 3 April 2024

Introduction

Paracetamol is a majorly used over-the-counter pain reliever and fever reducer, also called acetaminophen. It's a common choice for the management of slightly to moderately painful symptoms. Paracetamol is widely used in the treatment of various conditions, from headache to muscle pain to fever associated with infection due to its safety profile. In this blog, we are going to look at the details of this important pharma compound including active pharmaceutical ingredient, market size, raw material suppliers, etc.

Active Pharmaceutical Ingredient (API)

In different formulations, paracetamol acts as an active pharmaceutical ingredient API. It is the paracetamol API that provides relief from body ache and fever when you reach for a product such as Crocin.

Raw Material and Manufacturing Process

1. Raw Material: phenol is the starting material for the manufacture of paracetamol. This phenol undergoes nitration to yield a mixture of ortho- and para-nitrotoluene. The o-isomer is removed, and the p-nitro group is reduced to form a p-amino group. In order to produce paracetamol, this intermediate is acetylated.

2. PNCB Route: The PNCB route is used by Farmson Pharmaceutical, a world leader in the manufacture of API paracetamol. They use p-nitrochlorobenzene (PNCB) as a key starting raw material. PNCB is converted to paracetamol by a series of biochemical processes. This method is cost efficient and beneficial for the environment.

Raw Material Suppliers

For the supply of chemicals for paracetamol production, a number of companies play an essential role. Notable suppliers include: 

  • IOL Chemicals and Pharmaceuticals Limited (India)
  • Temad Co. (Iran)
  • Rochem International Inc. (USA)
  • Jai Radhe Sales (India)
  • Suanfarma (Spain)

Market Players

India Paracetamol Market: Glaxosmithkline Pharmaceuticals Ltd., Granules India Limited and Farmson Pharmaceutical Gujarat Private Company are among the major players in that market. (Courtesy: Techsciresearch)

Market Size and Revenue:

The paracetamol global market size was valued at USD 1.6 billion in 2022. From 2023 to 2029, paracetamol revenue is expected to increase at a compound annual growth rate of 4.4 % and reach almost USD 2 billion. (Courtesy: Maximize Market research)

Factors Driving Growth: 

  • Widespread Availability: The demand was due to the availability of paracetamol as an over-the-counter OTC medicine.
  • Pain Management: It is widely used in the treatment of mild to moderate pain, including headaches, toothaches and osteoarthritis.
  • Antipyretic Properties: Paracetamol effectively reduces fever.
  • Increased OTC Use: Growing burden of indicative conditions and OTC use of paracetamol products.

Post-Pandemic Trends:

  • Paracetamol has been recommended for the treatment of fever in COVID 19 patients during the pandemic. 
  • Market players around the world have been strengthened by local production initiatives.

Effects and Future Aspects

  • PCM is highly effective and have an excellent safety record, making it one of the most important components in many medicines. 
  • The major challenge is to attain self-sufficiency in the manufacture of paracetamol's active substance pharmaceuticals API. Efforts are underway to reduce the reliance on China suppliers for critical materials such as para-aminophenols in a coordinated manner.
  • The main challenge is to achieve self-reliance in the manufacture of paracetamol API. 
  • The market's future impact on global health will be shaped by innovation and stable supply chains.

Chemxpert Database

The Chemxpert database, top global buyer supplier database in India, is an important tool in the pharmaceutical and life sciences sector. The paracetamol database of Chemxpert may be used for information on suppliers, buyers, market size, pricing mechanisms and other relevant data. It also provides regulatory information and clinical trial data on paracetamol.

In the paracetamol sector, Chemxpert, a comprehensive pharmaceutical database, plays an important role in connecting the dots. It makes it easier to understand the decisions, by providing an exhaustive list of manufacturers from major paracetamol producing countries such as India and China.

Chemxpert provides real time information on production levels, industry trends, regulatory compliance and market dynamics. The consistent leadership of Chinese and Indian companies on the paracetamol market is highlighted by regular evaluation. Overall, Chemxpert increases transparency, connects stakeholders and enables the rapid development of paracetamol research and manufacturing.

Conclusion

In conclusion, paracetamol is a medicine to help you deal with pain and fever. It is well used and has a number of benefits. The future of paracetamol seems bright because it is produced in a careful manner, the demand for this product is high and scientists are constantly working on its improvement.

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