The global active pharmaceutical ingredients industry is estimated to be worth $232.13 billion in 2025. By 2030, this figure is expected to reach $328.94 billion at a CAGR of 7.22%. The primary cause for this increase is the growing need for effective therapies, increased chronic disease prevalence, and the development of generic drug manufacturing.
All pharmacological formulations are built on APIs, which are what give a range of therapies their therapeutic efficacy. To ensure quality and innovation, API pharmaceutical companies are putting smart manufacturing technology into practice and placing a strong emphasis on regulatory compliance.
This blog is all about the leading API manufacturing businesses in the United States, noted for their creativity, regulatory standards, and large-scale production capabilities. We also introduce the top API pharma database company in the United States, which is an invaluable resource for discovering certified suppliers, thorough product catalogs, and manufacturing capabilities.
There is an array of API manufacturing companies in the USA majorly due to their robust research infrastructure and best in class manufacturing facilities.
Here is an in-depth look at some of the top API manufacturers in the USA as of 2025:
Pfizer CentreOne is a global contract development and manufacturing organization. It is a division of Pfizer specializing in API synthesis for complex and large-scale pharma projects.
Key Capabilities:
Certifications & Regulatory Strength:
Global Reach:
With decades of experience in manufacturing small molecule space, Cambrex is a leading U.S. –based CDMO. Cambrex offers end-to-end API development and manufacturing solutions, with numerous manufacturing sites across the country.
Key Capabilities:
Certifications & Regulatory Strength:
Global Reach:
Along with being one of the top API manufacturing companies in USA, Thermo Fisher Scientific also delivers integrated CDMO services through it’s Patheon brand. It has multiple high-capacity manufacturing with the U.S.
Key Capabilities:
Certifications & Regulatory Strength:
Global Reach:
Renowned technically challenging API manufacturing, ranging from energetic chemistry and controlled substances, there’s no doubt that Ampac Fine Chemicals is one of the best API manufacturing companies in USA. Their U.S. plants are equipped for both small and large scale API manufacturing processes.
Key Capabilities:
Certifications & Regulatory Strength:
Global Reach:
The U.S. arm of the Swiss CDMO giant, Lonza offers high-end manufacturing services for both biologic and chemical APIs. The company's U.S. facilities are designed to support innovation at every stage of the drug development lifecycle.
Key Capabilities:
Certifications & Regulatory Strength:
Global Reach:
Siegfried USA, LLC is part of the Swiss-based Siegfried Group, known globally for its high standards in pharmaceutical manufacturing. With its state-of-the-art facility in Pennsville, New Jersey, the company provides robust API manufacturing services tailored to both branded and generic pharmaceuticals.
Key Capabilities:
Certifications & Regulatory Strength:
Global Reach:
Ajinomoto Bio-Pharma Services operates a key US facility in San Diego, focusing on the development and manufacturing of APIs with a specialization in biopharmaceutical applications. Backed by its Japanese parent company, Ajinomoto Co., Inc., it combines innovation with deep expertise in fermentation and synthetic chemistry.
Key Capabilities:
Certifications & Regulatory Strength:
Global Reach:
As one of the largest API pharmaceutical companies based in the United States, AbbVie Inc. combines robust manufacturing capabilities with strong R&D leadership. Its vertically integrated operations ensure quality control across the full API lifecycle.
Key Capabilities:
Certifications & Regulatory Strength:
Global Reach:
Amgen Inc., headquartered in Thousand Oaks, California, is a biotechnology pioneer and one of the leading API manufacturers in USA specializing in biologics. Known for its science-driven innovation, Amgen has built a strong reputation for developing and producing complex biologic APIs.
Key Capabilities:
Certifications & Regulatory Strength:
Global Reach:
Eli Lilly and Company, based in Indianapolis, Indiana, is among the most respected API pharmaceutical manufacturers in the USA, with a legacy of over 145 years in the healthcare industry. Its API operations support a wide range of therapeutic areas including diabetes, oncology, neuroscience, and immunology.
Key Capabilities:
Certifications & Regulatory Strength:
Global Reach:
These companies exemplify the strength and sophistication of the API manufacturing industry in the USA.
Their focus on innovation, compliance, and scalability makes them integral players in the global API pharmaceutical ecosystem. In the following section, we will explore how to identify the most suitable API suppliers using a reliable pharma database.
If you are looking to source the most reliable and comprehensive API manufacturers’ data not only in U.S., but anywhere around the world, just a Google isn’t enough. Procurement, business development, and regulatory professionals need verified, in-depth insights to make informed decisions.
This is where Chemxpert Database adds real value. We are leading API and chemicals database provider that helps you streamline your sourcing process.
Whether you’re managing procurement, assessing regulatory risks, or conducting market research, Chemxpert Database gives you the tools to identify the right partner in the API manufacturing process — faster and with more confidence.
The USA continues to lead in API manufacturing with companies known for quality, innovation, and regulatory compliance. But choosing the right supplier takes more than a quick search.
Chemxpert Database simplifies the process by offering verified data on 250,000+ API products, certifications, DMFs, and more — helping you make confident sourcing decisions faster.
Whether you're in procurement, BD, or regulatory, Chemxpert Database is your go-to tool for finding trusted API manufacturers.
Sick and tired of always wondering if you are being asked to pay the right price for your APIs? This empowers you with the answers you need to make the right decisions in the Global API market.
Chemxpert Database is one of the biggest and most comprehensive directories of pharma and chemicals, manufacturers, suppliers and information. Provided with current information on prices, demand and transactions, it gives you instant feedback on whether you are buying what is right and at the right time.
Start using market intelligence today and allow yourself to be in control in the API market.
Check it out today and make more informed sourcing decisions! Learn More!