Sumitomo Pharma Oncology Announced The U.S. Food And Drug Administration (Fda) Granted Orphan Drug Designation For Tp-1287, An Investigational Oral Cdk9 Inhibitor, For The Treatment Of Ewing Sarcoma.Tp-1287 Exhibits Potent Inhibition Of Intracellular Kinases Including Cdk9. Inhibition Of Cdk9 Leads To Downregulation Of Key Antiapoptotic Proteins Such As Mcl-1, Which In Turn Has Been Shown To Inhibit Tumour Growth In Preclinical Models Of Haematologic Malignancies And Several Tumour Types.Tp-1287 Is Currently Being Evaluated In A Phase 1, First-In-Human Study Of Oral Tp-1287 In Patients With Advanced Metastatic Or Progressive Solid Tumours Who Are Refractory To, Or Intolerant Of, Established Therapy Known To Provide Clinical Benefit For Their Condition, Which Is Being Conducted In The United States.Ewing Sarcoma Is A Rare Type Of Cancer That Occurs In Bones Or In The Soft Tissue Around The Bones. The Disease Occurs When A Cell Develops Changes In Its Dna That Cause The Cell To Multiply Quickly, Resulting In A Tumour Of Abnormal Cells That Is Capable Of Invading And Destroying Healthy Body Tissue. The Abnormal Cells Can Break Away And Metastasise Throughout The Body. Ewing Sarcoma Can Occur At Any Age, But It Is More Likely To Occur In Children And Teenagers.
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