Parse Biosciences Launches Integrated Immune Repertoire and Whole Transcriptome Workflow in Trailmaker
Parse Biosciences has launched a fully integrated immune repertoire and whole transcriptome analysis workflow within its Trailmaker data analysis platform.
The update enables a complete end-to-end immune profiling solution. It complements Parse’s Evercode immune product portfolio and connects experimental data with downstream analysis in a single environment.
Solving a long-standing immunology data problem
Immunologists often analyze:
Immune repertoire sequencing data
Whole transcriptome single-cell data
But these datasets usually live in separate tools.
This fragmentation creates problems:
Manual stitching of pipelines
Custom scripts and inconsistent workflows
Limited ability to connect clonotypes with functional cell states
Trailmaker’s new functionality unifies these layers into one purpose-built platform.
What the new Trailmaker workflow enables?
Researchers can now:
Combine immune repertoire and whole transcriptome data
Visualize clonotypes and cell types on a single integrated UMAP
Identify dominant clones using frequency and honeycomb plots
Detect conserved motifs through unique motif analysis
Link clonotypes directly to transcriptional states
Run targeted differential expression on specific clonotypes
The result is a complete view of:
Clonal structure
Diversity
Antigen-driven signatures
Functional cell programs
Why this matters?
By connecting repertoire data with transcriptome-wide expression, Trailmaker:
Reveals clonotype-specific gene programs
Adds biological context to immune repertoire findings
Reduces analysis complexity and time
Researchers move faster from raw data to biological insight.
Company perspective
“Our goal has always been to remove barriers for researchers,” said Charlie Roco, PhD, co-founder and CTO of Parse Biosciences.
“By making immune profiling intuitive and more fully integrated, we’re empowering immunologists to spend less time wrangling data and more time assigning biological significance.”
The company’s mission is to accelerate progress in human health through high-scale single-cell biology.
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