Minghui Pharmaceutical (Minghui), a late-stage clinical biopharmaceutical company, announced an exclusive licensing and collaboration agreement with Qilu Pharmaceutical (Qilu) for the development, manufacturing, and commercialization of its B7-H3 ADC (MHB088C) in Greater China (including Mainland China, Hong Kong, Macau, and Taiwan).
Under the agreement, Qilu will obtain exclusive rights to MHB088C in the region, while Minghui will be eligible for total payments of up to 1.345 billion RMB, including: 280 million RMB upfront and a near-term milestone payment, 1.065 billion RMB in development, regulatory and sales milestone payments, and up to double-digit royalties on net product sales. Minghui will retain global rights to MHB088C outside Greater China and continue advancing its development in these regions.
MHB088C is an innovative B7-H3-targeted antibody-drug conjugate (ADC) developed using Minghui's proprietary SuperTopoi ADC platform. It is distinguished by its potent anti-tumour activity and superior safety profile, significantly expanding the therapeutic window.
In ongoing phase ?/? clinical trials, MHB088C has been evaluated in over 300 patients with advanced or metastatic solid tumours, demonstrating a favourable safety profile and promising efficacy. Subgroup analyses in small cell lung cancer (SCLC) and metastatic castration-resistant prostate cancer (mCRPC) will be presented at the ASCO 2025 Annual Meeting as oral and poster presentations, respectively. A phase ? trial in relapsed SCLC has been officially initiated in China, with the first patient being enrolled in a couple of weeks.
""Our collaboration with Qilu marks a significant milestone in Minghui's commitment to advancing innovative cancer therapies,"" said Dr. Guoqing Cao, CEO of Minghui. ""MHB088C has demonstrated robust efficacy with great safety profiles, with no major haematological toxicity or ILD, positioning the program as a best-in-class B7-H3 ADC. With Qilu's leadership and resources, we are confident that MHB088C will serve patients in need and contribute to the advancement of precision oncology in China.""
Minghui Pharmaceutical is a late-stage clinical biopharmaceutical company dedicated to developing innovative medicines to address unmet medical needs in oncology and autoimmune diseases.
Established in 1958, Qilu Pharmaceutical is now one of the leading vertically integrated pharmaceutical companies in China that develops, manufactures and distributes both finished dosage forms (FDFs) and active pharmaceutical ingredients (APIs).