Innovent Laekna Begin Patient Dosing In Phase 12 Trial Of Three Drug Combination To Treat Solid Tumours Who Were Resistant To Prior Anti Pd 1pd L1 Therapy
Innovent Laekna begin patient dosing in phase 1/2 trial of three drug combination to treat solid tumours who were resistant to prior anti-PD-1/PD-L1 therapy
Innovent Biologics, Inc., a world-class biopharmaceutical company, and Laekna Therapeutics, a clinical-stage biotechnology company, jointly announced that the first patient has been dosed in a phase 1/2 clinical trial of a three-drug combination therapy (afuresertib + sintilimab + chemotherapy) in patients with specific solid tumours who were resistant to anti-PD-1/PD-L1 therapy at the West China Second Hospital of Sichuan University. This marks a key milestone on the first anniversary of the clinical research partnership established between Innovent and Laekna in July 2021.
The study is a multi-center, single-arm, open-label, dose-escalation phase 1/2 clinical study, assessing recommended phase 2 dose (RP2D), safety, tolerability and anti-tumour activity of afuresertib in combination with sintilimab and chemotherapy (nab-paclitaxel or docetaxel) in patients with solid tumors who were resistant to prior anti-PD-1/PD-L1 therapy. The principal investigator of the study is Professor Lin Shen, director of the Department of Gastrointestinal Oncology of Beijing Cancer Hospital. The primary endpoints of the phase 1 dose escalation study are maximum tolerated dose (MTD) and RP2D, and the primary endpoint of the Phase 2 study is overall response rate (ORR). The study is planned to be extended as a multi-regional clinical trial at the pivotal stage.
The clinical trial assesses five types of solid tumours, including non-small cell lung cancer (NSCLC), gastric cancer/gastroesophageal junction cancer (GC/GEJC), esophageal cancer (EsC), cervical cancer (CC) and endometrial cancer (EC). The study focuses on the AKT inhibitor, a potential new therapy for drug resistant-cancer, to address the unmet medical needs in cancer immunotherapy resistance and bring hope to solid tumour patients who have received prior anti-PD-1/PD-L1 treatments.
The combination therapy consists of Laekna
Let’s apply Data-Driven Pricing to Your APIs
Sick and tired of always wondering if you are being asked to pay the right price for your APIs? This empowers you with the answers you need to make the right decisions in the Global API market.
Chemxpert Database is one of the biggest and most comprehensive directories of pharma and chemicals, manufacturers, suppliers and information. Provided with current information on prices, demand and transactions, it gives you instant feedback on whether you are buying what is right and at the right time.
Start using market intelligence today and allow yourself to be in control in the API market.
Check it out today and make more informed sourcing decisions!
Learn More!