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  3. Innocare Announces Approval Of Clinical Trial Of Bcl2 Inhibitor Icp 248 In China
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  • 13 Sep 2022
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InnoCare Announces Approval of Clinical Trial of BCL2 Inhibitor ICP-248 in China

InnoCare Pharma announced today that the Company has received Investigational New Drug (IND) approval of clinical trial from the NMPA (National Medical Products Administration) for its B-cell lymphoma-2 (BCL2) inhibitor ICP-248, which is the Company's fifth innovative drug to enter the clinical stage in the field of hematology, and also the 13th drug entering the clinic in the pipeline. ICP-248 is a novel, orally bioavailable BCL2 selective inhibitor, which aims to treat non- Hodgkin's lymphoma (NHL), acute lymphoblastic leukemia (ALL) and other malignant hematological tumors as a monotherapy or in combination with BTK inhibitors and other drugs. BCL2 is an important part of apoptotic pathway and is overexpressed in a variety of hematologic malignancies. ICP-248 has anti-tumor effects by activating the endogenous mitochondrial apoptosis pathway that causes rapid cancer cell apoptosis. Dr. Jasmine Cui, the Co-founder, Chairwoman and CEO of InnoCare said,

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