Exothera SA announced a collaboration with LogicBio Therapeutics and Polyplus-transfection SA for the development of a highly scalable AAV manufacturing platform with a capacity from 200 L to 2,000 L. Adeno-associated viruses (AAV) are non-enveloped, non-pathogenic viruses largely used as drug delivery vectors for biotherapeutics, like gene therapies and vaccines. Although the application of AAV is spreading rapidly, the industry is struggling to find cost-effective manufacturing strategies to reach clinical and commercial scales. The collaboration among Exothera, LogicBio, and Polyplus aims to focus on the scale-up of a transient transfection-based AAV serotype 8 (AAV8) manufactured in suspension cell culture. The consortium selected the Allegro stirred tank Single-Use Bioreactor (from Pall) as a suspension culture device due to its scalability and single-use features. The project aims to assess reproducibility and comparability between the different scales of suspension bioreactors, up to 2,000 L bioreactor scale. Exothera will provide state-of-the-art production space, process development expertise and access to the latest enabling technologies. LogicBio will support the initiative with its mAAVRx plasmid technology and its AAV expertise. Polyplus will provide transfection reagent expertise with FectoVIR-AAV for a smooth scaled-up GMP-eligible process development. Hanna Lesch, chief technology officer at Exothera:
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