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  3. Daiichi Sankyo Begins Patient Dosing In Tropion Breast01 Phase 3 Trial Of Datopotamab Deruxtecan In Patients With Hr Positive Her2 Negative Metastatic Breast Cancer
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  • 22 Nov 2021
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Daiichi Sankyo begins patient dosing in TROPION-Breast01 phase 3 trial of datopotamab deruxtecan in patients with HR positive, HER2 negative metastatic breast cancer

Daiichi Sankyo Company, Limited announced that the first patient was dosed in the global TROPION-Breast01 phase 3 trial evaluating the efficacy and safety of datopotamab deruxtecan (Dato-DXd), a TROP2 directed DXd antibody drug conjugate (ADC) being jointly developed by Daiichi Sankyo and AstraZeneca, in patients with hormone receptor (HR) positive, human epidermal growth factor 2 receptor (HER2) negative inoperable or metastatic breast cancer previously treated with chemotherapy. Breast cancer is the most common cancer worldwide with more than two million cases diagnosed in 2020, resulting in nearly 685,000 deaths globally. Approximately 70% of all breast cancers are considered HR positive, HER2 negative. For patients with HR positive, HER2 negative metastatic breast cancer that progresses on or is not suitable for hormone therapy-based regimens, current standard of care is single-agent chemotherapy, which demonstrates diminishing efficacy with each subsequent line of treatment.

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