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08 Nov 2024
Admin
News Article

Bespak, Orbia Fluor & Energy Materials Collaborate to Accelerate Transition to Climate-Friendly Inhalers

Overview

Bespak, a specialist inhalation contract development and manufacturing organisation (CDMO), and Orbia Advance Corporation, S.A.B. de C.V. (BMV: ORBIA) Fluor & Energy Materials (Koura), a global leader in the development, manufacture, and supply of fluoroproducts and technologies, announced a collaboration intended to accelerate the transition to climate-friendly inhalers utilising Orbia Fluor & Energy Materials’ low global warming potential (GWP) propellant known as Zephex 152a.

Bespak on Feasibility of MDI Formulations

As a result of its commitment to the pMDI industry’s transition from currently-used propellants to more sustainable solutions, Bespak has verified the feasibility of leading marketed pMDI formulations with low GWP propellants – an achievement enabled by its market-leading range of valves and its network of expert partners, underpinned by its own footprint encompassing GLP lab-scale formulation feasibility, product development and analytical testing, clinical-scale GMP capability and commercial-scale GMP manufacturing.

Bespak Post Investments

Following significant investments, Bespak can now provide development services up to market approval for all pMDI formulations and propellants, supported by capacity for commercial supply.
Most recently, Bespak announced the availability of its clinical supply services utilising HFA-152a as a result of its partnership with H&T Presspart, and its investment in a new high-speed commercial-scale filling line capable of manufacturing with HFA-152a, both at the company’s Holmes Chapel site.

Aim & Objectives of the Collaboration

Combining Orbia Fluor & Energy Materials’ innovation in propellant technology and its own GLP and clinical-scale GMP capability with Bespak’s leading position in pMDI componentry and services, the shared aim of the collaboration is to advance understanding and enable success in the reformulation and commercialisation of pMDI products globally.
The companies will focus their activities in their teams working in close geographical proximity at their sites in the North West of England, well-known historically for its pMDI knowledge base.
In addition, the technical support provided by Bespak’s team in King’s Lynn, UK, which has conducted research and development over the past five years to advance a range of valves and actuators to ensure unmatched performance with the new generation of propellants, will result in further speed and agility in the reformulation and development process.

Words from the CEO: Bespak

Chris Hirst, CEO of Bespak, commented: “We are committed to leading the transition to low GWP propellants in pMDIs, and in collaboration with Orbia Fluor & Energy Materials, we will enable customers to progress their inhaler portfolios utilising Zephex 152a.”
“Our goal is to convert as many formulations as possible to maintain patient access to pMDIs as global regulation evolves, and we look forward to working with Orbia Fluor & Energy Materials to provide customers with a pathway to commercialisation at our Holmes Chapel site.”

From Orbia Fluor & Energy Materials Pharma Business Unit

Markus Laubscher, general manager of Orbia Fluor & Energy Materials Pharma Business Unit, said: “This is another step forward in bringing pMDIs using our low GWP medical propellant Zephex 152a to the market. We are excited to extend our industry collaborations to Bespak who bring the needed capabilities to the table, from their expertise in valves and actuators, to their demonstrated commitment to clinical and commercial-scale product manufacturing.”

About the Company: Bespak

Bespak is a global contract development and manufacturing organisation (CDMO) focused on inhaled and nasal drug delivery devices and drug-device combination products.
Bespak develops and manufactures finished pharmaceutical products, as well as being a leading global supplier of drug delivery devices and componentry to the pharmaceutical industry.

About Orbia Advance Corporation

Orbia Advance Corporation, S.A.B. de C.V. (BMV: ORBIA) is a company driven by a shared purpose: to advance life around the world.
Orbia operates in the Polymer Solutions (Vestolit and Alphagary), Building and Infrastructure (Wavin), Precision Agriculture (Netafim), Connectivity Solutions (Dura-Line) and Fluor & Energy Materials (Koura) sectors.

About Fluor & Energy Materials Business

Orbia’s Fluor & Energy Materials business (Koura) is a global leader in the development, manufacture and supply of fluoroproducts that play a fundamental role in enhancing everyday lives and shortening the path to a sustainable, circular economy.
Backed by over 35 years of experience, its products are used in a vast range of applications including electric vehicles and energy storage, urban and rural infrastructure, indoor climate management, food and medicine refrigeration and even in treating respiratory conditions through the development of healthy and innovative low-GWP propellants for metered dose inhalers.

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