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  3. Arecor Trx Biosciences Partners For Oral Glp 1 Therapy
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  • 14 Mar 2024
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  • News Article

Arecor & TRx BioSciences Partners for Oral GLP-1 Therapy

Arecor and TRx BioSciences Establish Partnership for Advancing Oral GLP-1 Therapy with Improved Bioavailability

Arecor Therapeutics plc (AIM: AREC), a biopharmaceutical company focused on advancing modern therapies for improved health outcomes, has teamed up with TRx Biosciences Limited, a leader in innovative lipid technology for oral drug delivery. Together, they have announced a research collaboration aimed at formulating an oral glucagon-like peptide-1 (GLP-1) receptor agonist product.

GLP-1 Receptor Agonists: Funds & Challanges

  • GLP-1 receptor agonists are crucial for managing type 2 diabetes and obesity. 
  • The global market for these treatments is projected to reach $80-$100+ billion by 2030. 
  • However, delivering these drugs orally presents significant challenges due to the digestive system's proteolytic nature, resulting in reduced bioavailability. 
  • Currently, injection remains the primary delivery method, limiting patient adoption, compliance, and usage.
  • Aim for thi collaboration
  • The only oral GLP-1 receptor agonist available to patients is Novo Nordisk’s semaglutide (Rybelsus®), which boasts less than 1% oral bioavailability. 
  • To address this issue, Arecor and TRx Biosciences plan to utilize TRx Biosciences’ LipiCore™ oral delivery technology along with Arecor’s formulation platform, Arestat™. 
  • This collaboration aims to develop an oral GLP-1 receptor agonist product with improved physicochemical properties to achieve higher oral bioavailability and stability.

Arecor CEO on Challanges

  • Sarah Howell, CEO of Arecor, highlighted the ongoing challenges in oral delivery for GLP-1 receptor agonists and expressed optimism in leveraging Arecor's Arestat™ technology alongside TRx Biosciences' expertise to develop an enhanced oral product. 
  • Dr. Robin Bannister, CEO of TRx Biosciences, emphasized the importance of effective oral peptide delivery and the potential of combining LipiCore™ with Arecor's platform to unlock novel oral uptake channels and protect peptides during gastrointestinal transit.

Novel GLP-1 Receptor Agonist

  • The collaboration aims to extend beyond the initial GLP-1 receptor agonist program to develop additional oral peptide products, potentially targeting obesity-related health conditions and other therapeutic areas. 
  • Success in this endeavor could revolutionize oral peptide therapy, providing patients with more convenient and effective treatment options.

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