This study is the third ATG-016 study to be conducted in China. Study highlights Antengene's robust SINE programs. Antengene Corporation Limited a leading innovative, commercial-stage global biopharmaceutical company dedicated to discovering, developing and commercializing first-in-class and/or best-in-class medicines for cancer, today announced the China National Medical Products Administration (NMPA) has approved a Phase II open-label study designed to evaluate the safety, tolerability and efficacy of the next-generation selective inhibitor of nuclear export (SINE) compound ATG-016 in patients with high-risk myelodysplastic syndromes (MDS).ATG-016 is being developed for treating patients with MDS or solid tumors. ATG-016 and other SINE compounds inhibit the nuclear export protein called Exportin 1 (XPO1) that helps cancers grow by removing tumor suppressor proteins from the nucleus. ATG-016 is an orally-active, highly-specific next-generation XPO1 inhibitor with an improved pharmacological profile versus the first novel SINE compound, ATG-010/selinexor/XPOVIO
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