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  3. Alteogen Enters Into Agreement With Daiichi Sankyo For Enhertu Development Using Hybrozyme Technology
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  • 12 Nov 2024
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Alteogen Enters into Agreement with Daiichi Sankyo for ENHERTU® Development Using Hybrozyme™ Technology

Overview

Alteogen has announced an exclusive licensing agreement with Daiichi Sankyo granting the latter global rights to leverage ALT-B4, Alteogen’s innovative hyaluronidase created with Hybrozyme™ Technology.

About ALT-B4

ALT-B4 is Alteogen’s proprietary human recombinant hyaluronidase enzyme, developed with the company’s Hybrozyme™ Technology, allowing drugs typically delivered through intravenous (IV) infusion to be administered subcutaneously.

Benefits of Technology

This technology will be used to develop and commercialize a subcutaneous version of ENHERTU® (fam-trastuzumab deruxtecan-nxki), a HER2-targeting antibody drug conjugate (ADC) jointly developed by Daiichi Sankyo and AstraZeneca.

Terms of the Agreement

Under the terms of the agreement, Alteogen will receive an initial payment and may earn additional milestone payments, contingent on the progress of specified development, regulatory, and sales targets met by Daiichi Sankyo. 

Tiered Royalties: for Alteogen

  • Alteogen is also set to receive tiered royalties based on product sales following commercialization. 
  • Additionally, Alteogen will supply ALT-B4 to Daiichi Sankyo for both clinical and commercial needs.

This is achieved by temporarily hydrolysing hyaluronan in the extracellular matrix, thus enabling the subcutaneous administration of large-volume medications.

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