Alembic Pharma announced that its associate company, Rhizen Pharmaceuticals, has entered an license agreement with Curon Biopharmaceutical for development and commercialisation of Tenalisib, in Greater China.Under the terms of the agreement, Rhizen will receive an undisclosed upfront cash payment and is eligible to receive additional development and commercial milestone payments with an overall deal value of US$ 149.5 million (approximately Rs. 1,047 crore) plus double-digit royalties on annual net sales of Tenalisib.Curon obtains the exclusive development and commercialisation rights of Tenalisib for Greater China across all oncology indications and will lead the clinical development in that territory by leveraging its expertise in translational research, clinical development and regulatory registration and its extensive research collaboration experience, to accelerate the development of and regulatory approval of this product in Greater China.Swaroop Vakkalanka, Ph.D., president and chief executive officer of Rhizen Pharmaceuticals stated, "Emerging human clinical data demonstrates that Tenalisib is a differentiated, next generation, orally active, dual PI3K a and ? inhibitor with an excellent safety profile and promising single-agent activity in haeme malignancies. We believe, Tenalisib's outstanding safety could allow rational combinations with other approved/investigational agents and enable us to unlock the true potential of this class of drugs. Our partnering with Curon is a first step towards achieving this objective and we look forward to the day this novel drug reaches cancer patients in need of new and safe therapies.""Tenalisib has demonstrated great efficacy in lymphoma patients with outstanding safety profile, in-licensing this product to China would bring more effective and additional treatment options to Chinese cancer patients and greatly benefit these patients. Meanwhile, this will further enrich our diversified pipeline. We are very happy and look forward to closely collaborating with Rhizen to efficiently develop this molecule into an effective medicine to benefit patients not only in China but also around the world as soon as possible," said Zhihong Chen, Ph.D., president of Curon.Rhizen Pharmaceuticals is a Switzerland-based privately-held clinical-stage biopharmaceutical company, and Curon Biopharmaceutical is a clinical-stage innovative biopharmaceutical company with facility in Shanghai.
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