1. What is the Chemxpert database?

Chemxpert database is a techno-commercial information platform developed and operated by Lifescience Intellipedia Pvt. Ltd. Our data provides valuable insights regarding sourcing, marketing, development, and regulatory functions for the entire Lifescience industry. The different industries covered by our data encompass APIs, FDFs, pharma intermediates, paints, dyes, polymers, biotechnology, biochemical, food additives, nutraceuticals, etc.

2. How can I subscribe to the Chemxpert database?

You can gain access to the Chemxpert database after subscribing to it by visiting this link: - https://chemxpert.com/pricing

3. How many countries' data is available on your portal?

The Chemxpert database covers more than 200 countries. We are working in the direction of expanding our data coverage in more countries.

4. What are the different sources you use for obtaining information?

The different sources we use for data collection are as follows: - • Primary researc • DMF, ANDA, & CEP list • Conferences, Exhibitions, & Tradeshow • Company annual reports • DMF, ANDA, & CEP list • Subject matter experts & KOL survey. Apart from these, our other valuable sources include application-wise manufacturers list, subscribed and non-subscribed databases, corporate partners, US FDA Orange book, publicly available sources, industry associates, national statistics, regulatory websites, etc. You can gain access to the Chemxpert database after subscribing to it by visiting this link: -https://chemxpert.com/sources

5. What is the expected time for account activation?

Your Chemxpert account will be activated instantly if the payment is made through our website. If you choose to use RTGS, NEFT, or IMPS systems for payment, your account will be activated within 24 hours.

28 Nov 2025
Admin
News Article

Gan & Lee Begins GRADUAL-3: A New Phase 3 Trial for Its Once-Monthly GLP-1 Bofanglutide

Gan & Lee Pharmaceuticals has launched GRADUAL-3, its third large-scale Phase 3 study for bofanglutide, a next-generation GLP-1 receptor agonist for obesity and overweight.

This study explores a simple idea with huge potential: Can a once-monthly GLP-1 injection maintain weight loss and boost long-term adherence?

What GRADUAL-3 Will Test?g

GRADUAL-3 will evaluate the efficacy and safety of once-monthly bofanglutide over 24 weeks.

Key details:

Subcutaneous injection given every four weeks.
Tests whether monthly dosing sustains weight loss.
Assesses long-term patient adherence with fewer injections.
Primary endpoints:
- Change in body weight from baseline at Week 24.
- Percentage change in body weight at Week 24.
Led by Prof. Linong Ji of Peking University People’s Hospital.

The study is registered as CTR20254659.

What We Know From Earlier Trials?

Gan & Lee has already run two major Phase 3 studies: GRADUAL-1 and GRADUAL-2.

GRADUAL-1

A 52-week study in around 630 adults with obesity or overweight. It evaluated the weight-loss efficacy and safety of bofanglutide.

GRADUAL-2

A 52-week head-to-head study with semaglutide 2.4 mg (Wegovy®). It is the first global GLP-1 RA trial comparing a new candidate directly with Wegovy in Chinese adults. Participants included adults with or without type 2 diabetes.

What These Studies Indicate?

Strong weight-loss effects.
Glucose-lowering benefits.
Improvements in metabolic parameters and cardiovascular risk markers.
A safety profile consistent with current GLP-1 drugs.

Why GRADUAL-3 Matters?

The biggest challenge with GLP-1 therapies is long-term adherence. Weekly injections work—until people stop taking them.

A monthly regimen could:

Reduce treatment fatigue.
Improve adherence.
Help sustain weight loss.
Limit weight regain seen after stopping GLP-1 therapy.
Offer a more convenient real-world solution.

Inside the GRADUAL Clinical Program

The GRADUAL program includes three major Phase 3 trials with a planned enrollment of more than 1,000 participants.

The three trials:

GRADUAL-1
- 52 weeks
- ~630 adults
- Tests weight-loss efficacy and safety.
GRADUAL-2
- 52 weeks
- ~471 adults
- Compared with Wegovy
- Includes participants with and without type 2 diabetes.
GRADUAL-3
- 24 weeks
- Tests once-monthly dosing for weight-loss maintenance.

About Bofanglutide

Bofanglutide (GZR18) is Gan & Lee’s novel GLP-1 receptor agonist.

Current development focus:

Obesity and overweight
Type 2 diabetes

Clinical profile so far:

Strong weight-loss effects
Effective glucose lowering
Broad metabolic benefits
Safety comparable to marketed GLP-1 RAs

Bofanglutide is now advancing through global Phase 3 development.

Let’s apply Data-Driven Pricing to Your APIs

Sick and tired of always wondering if you are being asked to pay the right price for your APIs? This empowers you with the answers you need to make the right decisions in the Global API market.

Chemxpert Database is one of the biggest and most comprehensive directories of pharma and chemicals, manufacturers, suppliers and information. Provided with current information on prices, demand and transactions, it gives you instant feedback on whether you are buying what is right and at the right time.

Start using market intelligence today and allow yourself to be in control in the API market.

Check it out today and make more informed sourcing decisions! Learn More!